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KMID : 1134820220510030205
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Journal of the Korean Society of Food Science and Nutrition
2022 Volume.51 No. 3 p.205 ~ p.212
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Improvement Effects on Inflammatory Bowel Disease of Ethanol Extract Isolated from Saururus chinensis
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Nam A-Youn
Lee Dong-Sun
Shin Kwang-Soon
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Abstract
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This study aimed to evaluate the in vivo efficacy of the ethanol extract of Saururus chinensis (SCES) on dextran sulfate sodium (DSS)-induced colitis at different oral doses (25, 50, and 100 mg/kg). The administration of SCES restored the body weight lost by DSS-induced colitis mice and improved colitis symptoms such as stool consistency and rectal bleeding. In addition, the DSS-administered mice showed a significant shortening of colon length, which was significantly improved by all the doses of SCES. Furthermore, we measured the myeloperoxidase (MPO) and pro-inflammatory cytokine levels [interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?)] to determine the degree of inflammation. MPO was significantly lower in the SCES-administered group in a dose-dependent manner compared to the DSS group. The levels of inflammatory cytokines (TNF-? and IL-6) were lower in the SCES administered groups than in the DSS group, whereas the SCES-administered group showed a higher production of immunoglobulin A (IgA). Colon histology showed that higher mucin (MUC2) content was retained in the SCES-administered group compared to the DSS group. Furthermore, oral administration of SCES enhanced the production of short-chain fatty acids, especially butyric acids by microbiota in the cecum. Based on these results, we suggest that SCES can be used as a novel therapeutic candidate against inflammatory bowel diseases.
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KEYWORD
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Saururus chinensis, MUC2, short-chain fatty acid, inflammatory bowel disease
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